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A team led by Martin Fussenegger of ETH Zurich in Basel has shown that caffeine can be used as a trigger for synthetic genetic circuitry, which can then in turn do useful things for us – even correct or treat medical conditions. For a buzz-worthy proof of concept, the team engineered a system to treat type 2 diabetes in mice with sips of coffee, specifically Nespresso Volluto coffee. Essentially, when the animals drink the coffee (or any other caffeinated beverage), a synthetic genetic system in cells implanted in their abdomens switches on. This leads to the production of a hormone that increases insulin production and lowers blood sugar levels – thus successfully treating their diabetes after a simple morning brew.